The effects of Omeprazole and antacids on electrolytes level were investigated in twenty-four (24) male and female matured rats induced with gastric ulcer for 30 days. The study was divided into 6 groups. Group 1 – control, Group 2 – Ulcer without treatment while 2 – 5 groups were given combined treatments (Omeprazole and Antacids) group 6 had only omeprazole treatment. Sodium, Potassium, calcium chloride and bicarbonate were the electrolytes assayed.
Plasma sodium was higher in group 6 (p<0.05) than other groups while sodium in group 5 was insignificantly different from groups 1,2,3,4 and 6 (p<0.05). The mean potassium was different between the groups, (p<0.05) and potassium in group 2 was significantly higher than the entire group (p<0.05). Magnesium in group 3 was significantly higher than groups 1 and 2, (p<0.05) while in groups 4, 5 and 6 magnesium were significantly less than that of group 2 and 3 (p<0.05). There was a significant increase in calcium in groups 5 than those of groups 1, 2, 4 and 6 (p<0.05). There was also a significant decrease in bicarbonate level in group 3 than group 1, (p<0.05), but the value in group 5 was significantly less than in group 1 and 4 (p<0.05). Chloride in group 2 was higher than group 3 (p<0.05) while those of group 4, 5, and 6 were less (p<0.05). It is shown in the study that therapy of omeprazole and antacids in ulcer treatment vary the electrolytes concentration which may affect body function.