Igf-i and zinc as a biomarker in early diagnosing cardiovascular complications in type 2 diabetics in the central india

Introduction: Diabetes mellitus (DM) is a group of metabolic diseases which if not controlled can cause life threatening complications. We hypothesize that serum IGF-1 and Zinc levels can be used as a Biomarker for early diagnosing cardiovascular complications in the Type 2 Diabetic patients in the Central India.
Methods and Materials: Fasting (FBS) and Post meal blood sugar (PMBG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), triglyceride (TG), Insulin Like Growth Factor-1 (IGF-1) and Zinc (Zn) levels were evaluated. Total sample size was 80, which was divided into 40 study group with type 2 DM who attended the Medicine OPD of AVBRH Hospital, Wardha and 40 age and sex matched healthy controls included in the study. Study period from June 2017 to June 2018.
Statistical Analysis: Software used in the analysis were SPSS 22.0 version and GraphPad Prism 6.0 version.
Results: Serum lipid profile showed higher mean of TC, TG and LDL in patients with diabetes. IGF-1 and Zinc level was significantly lower in subjects with diabetes as compared to the controls (p<0.0001). IGF-1 shows positive correlation with all the parameters.
Conclusions: Early detection of IGF-1, Zinc and lipid profile abnormalities can minimize the risk for development of cardiovascular complications in the type 2 diabetic patients. IGF-1 and Zinc levels may be a useful biomarker for identifying subjects at risk for cardiovascular complications in the Type 2 diabetics.