Tooth loss is a widespread concern. Prosthetic rehabilitation by all- on- 6 implant placement is a widely used procedure for full arch rehabilitations. It requires proper case selection with availability of sufficient bone and interarch space for fabrication of implant retained prosthesis. Although research into dental implant designs, materials, and processes has increased in recent years and is expected to continue. A computer-guided surgery is preferable for controlled and precise implant placement. Also, the exact implant angulations can be visualized to provide the best possible aesthetics and occlusion. Surgical guide can be used to perform a flapless surgical implant placement, reducing post-operative trauma. This case report describes the prosthetic rehabilitation of the mandibular arch by flapless surgical placement of six implants using a surgical guide and rehabilitated by hybrid prosthesis.