Family members of patients with schizophrenia have enormous roles in the care of their patients, which could negatively impact their well being. Development of interventions targeted at alleviating the burden of informal care giving is hinged on the recognition of the factors associated with the various dimensions of burden. This study was carried out with the aim to assess the caregiver burden among caregivers of patients with schizophrenia. The present study was conducted at the Mercy psychiatry hospital, Trichy. The present study was a cross sectional hospital based study. The sample comprised of 56 Caregivers patients with schizophrenia. The following tools were used: Socio-demographic data sheet and family burden interview schedule developed by Pai & R.L.Kapur (1981). The result showed that Majority (32.8 %) of the of the caregivers belong to age group of 51-60 years, (56.9 %) of the caregivers were female sex, (87.9 %) of the caregivers are married , 70.7 % of the caregivers belongs to Hindu religion, 53.4 % of the caregivers were studied up to Higher secondary , 65.5 % of caregivers belongs to Rural background. This study findings indicates that caregivers of patients with schizophrenia experiencing enormous burden and they need to be given proper attention and psychosocial intervention to reduce their burden and increase their quality of life.