Evaluation of two different dosages of dexmeditomidine in attenuation of pressor response during laryngoscopy and endotracheal intubation

Introduction: Pressor response to laryngoscopy and intubation have been associated with sympathetic and parasympathetic responses like Hypertension, Tachycardia due to increased plasma catecholamine concentrations. Premedication with Dexmedetomidine attenuates pressor response to laryngoscopy and intubation. Aims and Objective: to evaluate and compare effects of 2 different doses of Dexmedetomidine 0.5g/kg and 1 g/kg in attenuating pressor response to laryngoscopy and intubation. Methods: 60 patients aged 18-50 years of either sex of ASA grade I and II scheduled for elective surgery were randomly divided into 2 groups. All patients were uniformly premedicated with inj glycopyrolate 0.2mg and inj midazolam 1mg 10 mins before induction. Group A received Inj Dexmedetomidine 0.5g/kg and Group B received Inj Dexmedetomidine 1g/kg iv. After induction with Thiopentone and succinylcholine, laryngoscopy and intubation was done. HR, SBP, DBP were recorded for both groups before premedication, 10min after premedication and 1min, 2min, 3min, 5min, 7min,10min after intubation. Data was analyzed and compared with paired t test. Results: HR and BP levels were lower at 10min after premedication and 5min after intubation than baseline levels in both groups. But in Dexmedetomidine 1g/kg group amount of increase in HR, SBP, DBP were lower compared to 0.5 g/kg. Conclusion: Dexmedetomidine 1g/kg is more effective than 0.5 g/kg in attenuating pressor response to laryngoscopy and intubation and provides more stable hemodynamic profile.