Urolithiasis has affected the mankind for long years and these stones have caused progressive renal impairment. These patients usually present with characteristic loin pain, vomiting, sometimes fever, some patients may also be asymptomatic at times. Urinary calculi may cause various complications like obstruction, infection and renal failure. Obstructive uropathy refers to the structural impedance to the flow of urine anywhere along the urinary tract leading to hydronephrosis. In this study we evaluated the preoperative and postoperative radiological and biochemical changes of obstructive uropathy in 40 cases of renal or ureteric calculus with renal cortical thickness of minimum 4 mm. After 1 month and 3 months the relief in obstruction was studied by repeating the tests. It was found that urea, creatinine levels took about 3 months to get normalized. Ultrasonography & Intravenous pyelography at 3 months showed near complete normalization of hydronephrosis, however at one month few cases still had hydronephrosis.