Objective: The present study was intended to evaluate the cardioprotective activity of (METCL) methanolic extract of Terminalia catappa leaves.
Method: The methanolic extract of Terminalia catappa leaves at the dose of 100, 250 and 500 mg/kg was administered orally to Wistar albino rats with Doxorubicin (2.5mg/kg) induced myocardial infarction. Ascorbic acid (20mg/kg) was given as standard reference drug.
Results: Effect of METCL on serum enzymes and biomarkers
Rats intoxicated with Doxorubicin exhibited significant elevation in the levels of Aspartate amino Transferase (AST), Alkaline Phosphatase (ALP), Creatine kinase (CK), CK-MB and Lactate Dehydrogense(LDH) as compared to normal group. Animals pre-treated with graded doses of (100, 250 and 500 mg/kg) METCL significantly reduced the elevated levels of AST, ALP, CK, CKMB and LDH in a dose dependent manner as compared to Doxorubicin treated group.
Effect of METCL on serum cholesterol and triglycerides
Significant increase in the levels of serum cholesterol and triglycerides monitored in Dox administered group compared to normal control. Dose dependent significant reversal of these two lipids demonstrated in animals pre-treated with METCL compared to Doxorubicin treated group.
Conclusion: The results of the present study conclude that methanolic extract of Terminalia catappa leaves possesses significant cardioprotective activity against Doxorubicin induced cardiotoxicity in albino rats. This observed activity may be due to the presence of flavonoids and tannins in the test extract and may be linked to its antioxidant property.
