Evaluating the response to the neoadjuvant therapy for locally advanced rectal cancers

Tolga Önder., Aras Emre Canda and Cem Terzi

Introduction: Colcorectal cancers are the most important causes of the morbidity and mortality in the world. After only the surgical treatment, local recurrence occurs at rates ranging 5-50% and because of the difficulties with there laps therapy, the search of the adjuvant therapy has emerged. We aimed to assess the relationship between pre-neo adjuvant therapy CEA levels and response measures to neoadjuvant therapy and tumor regression degrees established in histopathologic examination.

Materials and Methods: A total of 138 patients whose data were accessed completely were enrolled in study. According to the CRT protocol, with the radiotherapy, intravenous 5-FU 225mg/m2/g of plant (5 days per week) was applied by continuous infusion in all patients. After 6-8 weeks from the neoadjuvant therapy. All patients underwent radical resection with TME technique. If pathology specimen had no tumor cells- pT0N0- ypTY called complete response, N stage regression called partial response (KY), T stage regression called TG. If there was not any regression was called ‘’ no response ‘’. In statistical analysis SPSS for Windows version 15.0 was used.

Results: Clinical characteristics of the 138 patients, included in the study, evaluated, 49 patients (35.5%) were female and 89 patients (64.5%) were male. Patients' mean age was 58 ± 13 years (range, 21-87).

Conclusion: According to our study, Wheeler Regression Score is not seen as an influential factor to evaluate the response to the neoadjuvant treatment. As a result, patients with preoperative ≤ 5 ng / ml CEA value, are more likely to respond to neoadjuvant therapy.

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DOI: http://dx.doi.org/10.24327/23956429.ijcmpr20170070