Background: Unhealed and chronic wounds create significant health care problem and enhance financial burden of society. This study was conducted in experimental rat model to judge the effect of phenytoin on wound healing.
Material and methods: Wistar rats were divided into two groups, (n=6 each group) and a wound was created which was treated with petroleum jelly in group A and Phenytoin Cream in group B. The wound healing and epithelisation of wound was evaluated at day 4,8,12,16 and 20.
Results: Group A showed an average wound size of 348±13.0 on day 4, 278±10.5 on day 8, 119±9.8 on day 12, 86±9.2 on day 16 and 100% wound healing was observed day 20 onwards. Group B showed an average wound size of 265±10.0 on day 4, 180±8.0 on day 8, 78± 5.5 on day 12 and complete wound healing was observed day 16 onwards in the test group.