Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease of unknown etiology, but it is believed to result from abnormal T Cell mediated immune responses in which basal epithelial cells which are recognized as foreign body because of changes in the antigenicity of their cell surface. The treatment modalities in oral lichen planus are still empirical. Corticosteroids remain the mainstay of OLP therapy because of their activity in diminish cell-mediated immune activity. Corticosteroids are administered topically, intra-lesionally or systemically depending on the severity of disease. The prolong use of topical steroids for a period of greater than two weeks continuous use may results in mucosal atrophy and secondary candidiasis, and may increase the potential of systemic absorption. Herbal medicines can be suitable alternatives to synthetic drugs. Application of topical Curcumin can be suggested for treatment of OLP because of its desirable anti- inflammatory effects and insignificant side effects. This review enlightens the treatment of Oral Lichen Planus by means of Curcumin therapy.
