Correlation of body mass index with hs-crp in north indian overweight and obese healthy adults

Introduction: Obesity is being considered as a worldwide health threat and understanding its mechanism and its correlation with hsCRP can lead to an insight into timely intervention in lifestyle to prevent the complications of it. Obesity is a low grade chronic inflammatory state, suspected to promote cardiovascular diseases, diabetes mellitus, atherosclerosis etc.
Aim: To determine, if there is any association between obesity and High-sensitivity C-Reactive Protein (hs-CRP)
Materials and Methods: Fifty obese and overweight subjects were included in study after following inclusion and exclusion criteria strictly. Anthropometric parameters were measured which included height, weight, hip circumference, waist circumference, W:H ratio. BMI was calculated and after following Asia Pacific standard overweight and obese were selected. hs CRP levels were measured . The data was expressed as mean and standard deviation (SD) or median, range and percentage as appropriate. Continuous variables in two groups were compared by t- test. Pearson’s correlation was used for correlation. The p-value <0.05 was considered as significant. The statistical analysis was done using SPSS 23.0 version (Chicago, Inc., USA) windows software
Results: .The mean age of study cases was 38.82±7.81 years in which the mean age of females was 39.18±8.38 years and of males was 38.64±7.62 years.
The mean height of study cases was 163.62±8.33 cm in which the mean height of females was 155.06±5.43 cm and of males was 168.03±5.70 cm.
The mean weight of study cases was 89.29±9.43 kg and found to be relatively more in females compared to males, while the mean waist circumference was 102.38±9.79 cm and found to be relatively more in males compared to females, but the Hip circumference was more in females. The mean W: H ratio of the study cases was 1.00±0.11, the mean BMI was 33.46±3.19 kg/m2.
The systolic and diastolic blood pressures had the mean 130.60±5.98 mmHg and 129.53±6.58 mmHg respectively.
The hs-CRP was significantly negative correlated with height whereas, significantly positive correlated with BMI and Diastolic BP.
Conclusion: A correlation pattern of inflammatory biomarker protein hs-CRP in obese human subjects was found. This may have a long-term impact in enabling us to know the methods for lowering hs-CRP levels that may help combat the issue of obesity in population throughout the world