Open cholecystectomy has been a gold standard for hundred years before the laparoscopic technique emerged. The purpose of this research was to compare clip application with suture ligation of the cystic duct and artery in patients undergoing open cholecystectomy. The time consumed after dissecting the triangle of Calot to ligating the structures was noted for each participant and leakage of bile was also observed post-operatively. A randomized control trial was performed, and patients were divided into two groups for allocation of clip or suture ligation. Out of the 95 patients 93.7% were females, 24.5% cases of suture ligations were performed in less than 5 minutes compared to 89.1% cases of clip ligation. Only 11 cases revealed biliary leakage post-operatively out of which suture ligation was performed in 10 cases. These findings show that clip ligation is a better option in terms of time consumption during procedure and biliary leakage after surgery.