Objectives: The goal of the prevailing study was to assess the efficacy and safety of intravenous paracetamol (1 gm) as opposed to intramuscular tramadol (100 mg) as an intrapartum labour analgesic. Materials and Methods: This was a prospective study carried out in Department of Obstetrics and Gynaecology in Rajah Muthiah Medical College and Hospital from 2015-2017 on 60 antenatal mother in active labour, after receiving the ethical clearance and written knowledgeable consent. The first 60 consecutive parturients fulfilling the inclusion standards had been recruited into the study. Women had been then randomised to obtain both intravenous one thousand mg (1000mg) of Paracetamol (Group A, n=30) or intramuscular a hundred mg(100 mg) of tramadol (Group B, n=30). Both the groups had been observed and compared for time of onset of analgesia, pain intensity was recorded by using Mc Gills scale before ,one and three hour after drug administration, duration of labour, maternal cardio respiratory parameters, mode of delivery, fetal APGAR scores, neonatal outcome and side effects of drugs. Results: No difference in pain intensity was visible earlier than drug administration. There was significant pain reduction after 1 and 3 hours of paracetamol administration compared to tramadol. Total duration of labour from enrolment in study to delivery in the paracetamol group changed was 276 mins (4 hrs36 mins) ± 59.97 minutes and in the tramadol group it was 393 minutes (6hrs 33mins) ±74 mins which concluded duration of labour was shortened in paracetamol group. In the paracetamol group, nausea was seen in 6.67% accompanied by vomiting (3.33%). Nausea became most commonest side effect in the tramadol group (13.3%) followed by vomiting (10%). APGAR scores in both groups had been satisfactory. Conclusion: Intravenous paracetamol was more effective labour analgesic with fewer maternal side effects and shortens labour in comparison to intramuscular tramadol.
