Schwannomas are benign, slow-growing tumors of peripheral nerve sheath and are rarely found in female genitalia. The most common locations for this tumor are head and neck, extremities, posterior mediastinum and retroperitonium Herein, we report a case of vulvar schwannoma in a 48 year old female, who presented with a large vulvar mass. Histopathologycal examination revealed a spindle cell neoplasm with arrangement of cells in short fascicles, whorls and a characteristic wavy nuclei in a nodular pattern. Few neoplastic spindle cells displayed pleomorphic nuclei with hyperchromasia with S-100 positivity. Inspite of its low incidence, plexiform schwannoma should be considered in the differential diagnosis of a cutaneous or subcutaneous mass in the vulva.
