We described a case of multi-vessel coronary endarterectomy due to diffuse coronary artery disease with multiple comorbidities. A 45-year-old man presented with features of ischemic heart disease (IHD) and on evaluation with coronary angiogram (CAG) patients was diagnosed as a case of Triple vessel disease with diffuse involvement of coronary artery. After evaluation patient undergone off pump coronary artery bypass grafting (OPCABG) with Coronary endarterectomy (CE) of left anterior descending artery (LAD), first Diagonal artery and right coronary artery (RCA) for total myocardial revascularization. There were no postoperative complications, and on the 11th post-operative day patient was discharged from the hospital in good ambulatory condition. Follow-up after 6 months, the bypass graft both native artery and conduits were patent.