The catabolic process of autophagy involves recycling of cellular elements and is thought to play a major role in etiopathogenesis of cancers. Autophagy is thought to buffer metabolic stress, thereby aiding in cell survival. Also, it is found that inhibiting autophagy under deficient nutrition can restore cell death to apoptosis. Therefore, autophagy has a dual role in cancer therapeutics. As oral cancers are major concern of worldwide deaths much research is required in the field of its progression and to determine positive treatment modalities. There exists a huge gap of knowledge to understand the process of autophagy, and it is beyond doubt that further research in this field would open up new doors of cancer prevention and treatment.