Association between dyslipidemia with major depressive disorder is complex and isdebatable. Lower levels of circulating lipid fractions and cholesterol are risk factors for impulsivity and depressive disorder.Thus aim of this study was to investigate the levels of serum lipids (cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, and VLDL-cholesterol LH ratio) and BMI in patients with major depression. Assess the severity, correlation and whether lipid components differ between depressed and non-depressed people. The study included 65 patients affected by depression. Diagnosis of major depressive disorder was made according to the criteria by applying HAMD and HAMA questionnaire.65 Age and sex matched healthy controls. Serum concentrations of cholesterol, triglycerides LDL-cholesterol and HDL-cholesterol were determined by enzymatic method. VLDL-cholesterol and LDL/HDL -cholesterol ratio were determined by calculation methods. The correlation was calculated using Pearson correlation coefficient. The P values were two tailed and probability level for significant difference was set at P < 0.05. In our result we found that Depressive symptoms were significantly associated with low total cholesterol, low triglycerides, low high-density lipoprotein cholesterol (HDL-C), low low-density lipoprotein cholesterol (LDL-C) and VLDL and also found associations of serum lipids with depressive symptoms were statistically significant. To conclude Elevated depressive symptoms are associated with low concentration of each component of lipid profile, showing inverse relationship associated with measures of depression and anxiety.